反应详情

A mixture of 25.3 g. of 6,7-ethylenedioxyquinazolin-4(3H)-one and 50 ml. of phosphorus oxychloride is refluxed for 10 minutes, cooled, and added with stirring to one liter of ice. After addition of concentrated ammonia the resulting mixture is extracted with chloroform and the chloroform solution chromatographed through 300 mls. of silica gel while eluting with chloroform. Evaporation of the eluent yields 4-chloro-6,7-ethylenedioxyquinazoline, m.p. 169°-174° C.

1. additionA mixture of 25.3 g
2. temperaturecooled
3. additionadded
4. extractionis extracted with chloroform
5. customthe chloroform solution chromatographed through 300 mls
6. washof silica gel while eluting with chloroform
7. customEvaporation of the eluent