Formamide → 6-(Dimethylamino)-3,4-dihydroquinazolin-4-one

HRID 596608Notes

Reaction equation

HRID 596608 reaction equation
[NH2:1][C:2]1[CH:10]=[CH:9][C:8]([N:11]([CH3:13])[CH3:12])=[CH:7][C:3]=1[C:4]([OH:6])=O.[CH:14]([NH2:16])=O>O>[CH3:12][N:11]([CH3:13])[C:8]1[CH:7]=[C:3]2[C:2](=[CH:10][CH:9]=1)[N:1]=[CH:14][NH:16][C:4]2=[O:6]

Participants

4

Reactant 2

HCID 713FormamideHCID 127157942-Amino-5-(dimethylamino)benzoic acid

Product 1

HCID 1358112116-(Dimethylamino)-3,4-dihydroquinazolin-4-one

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 14.6 g. of 2-amino-5-dimethylaminobenzoic acid and 75 ml. of formamide is refluxed for 40 minutes, cooled to room temperature, 100 ml. of water added, the crystals broken up and recovered by filtering. After washing several times with water, the solids are dried to obtain 6-dimethylamino-quinazolin-4(3H)one, m.p. 233°-236° C.

Workup

  1. additionA mixture of 14.6 g
  2. customrecovered
  3. filtrationby filtering
  4. washAfter washing several times with water
  5. customthe solids are dried

Sources & evidence

ORD record
ord-c5aa8f74a5524631be103275a770cc66
Source dataset
uspto-grants-1977_03
Patent number
US04011323

Reaction notes

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