HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formamide → 6-(Dimethylamino)-3,4-dihydroquinazolin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formamide | HCID 713 | — |
| Reactant | 2-Amino-5-(dimethylamino)benzoic acid | HCID 12715794 | — |
| Solvent | Water | HCID 962 | — |
| Product | 6-(Dimethylamino)-3,4-dihydroquinazolin-4-one | HCID 135811211 | — |
Reaction Steps
A mixture of 14.6 g. of 2-amino-5-dimethylaminobenzoic acid and 75 ml. of formamide is refluxed for 40 minutes, cooled to room temperature, 100 ml. of water added, the crystals broken up and recovered by filtering. After washing several times with water, the solids are dried to obtain 6-dimethylamino-quinazolin-4(3H)one, m.p. 233°-236° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04011323 |
| Source dataset | uspto-grants-1977_03 |
| ORD ID | ord-c5aa8f74a5524631be103275a770cc66 |
| Source note | uspto-grants-1977_03 |