反应详情

i. Hydrogen chloride was bubbled into a gently boiling solution of 3-(3-hydroxybenzoyl)propionic acid (40 g, 0.21 mole) in dry methanol (80 ml) until esterification was complete. The solution was poured into ice-water (700 ml) and the product extracted into ether. The combined ethereal solutions were washed in turn with water and sodium bicarbonate solution, dried, and finally evaporated under reduced pressure to give methyl 3-(3-hydroxybenzoyl)propionate (41g, 96 m.p. 101.5°-103° C). On recrystallisation from toluene, the pure ester had m.p. 102°-103.5° C.

1. extractionthe product extracted into ether
2. washThe combined ethereal solutions were washed in turn with water and sodium bicarbonate solution
3. customdried
4. customfinally evaporated under reduced pressure