Potassium Cyanide → HCID 16120964, compound

HRID 596696Notes

Reaction equation

HRID 596696 reaction equation
Cl.CN(C)[CH2:4][CH:5]([CH3:15])[C:6]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[OH:14])=[O:7].[C-:17]#[N:18].[K+]>O>[C:17]([CH2:4][CH:5]([CH3:15])[C:6]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[OH:14])=[O:7])#[N:18]

Participants

4

Reactant 2

HCID 9032Potassium CyanideHCID 21450236HCID 21450236, compound

Product 1

HCID 16120964HCID 16120964, compoundYield 93%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 2-(3-dimethylamino-2-methylpropionyl)phenol hydrochloride (2.70g), potassium cyanide (1.3g) and water (50 ml) was heated under reflux for 2 hours. The mixture was cooled, neutralised and extracted with chloroform. The extracts were dried (MgSO4) and the solvent was evaporated and purified by chromatography on a silica column to give 2-(3-cyano-2-methylpropionyl)phenol as an orange oil (1.95g).

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 2 hours
  3. temperatureThe mixture was cooled
  4. extractionextracted with chloroform
  5. dry with materialThe extracts were dried (MgSO4)
  6. customthe solvent was evaporated
  7. custompurified by chromatography on a silica column

Sources & evidence

ORD record
ord-f325097e9bc04fcebf5dc40219caf84c
Source dataset
uspto-grants-1977_03
Patent number
US04011321

Reaction notes

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