HCID 21450225, compound → HCID 21450248, compound

HRID 596702Notes

Reaction equation

HRID 596702 reaction equation
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([CH:19]=[CH:20][C:21]=1[N+:22]([O-])=O)[C:12]([CH2:14][CH2:15][C:16]([OH:18])=[O:17])=[O:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>[OH-].[NH4+]>[NH2:22][C:21]1[CH:20]=[CH:19][C:11]([C:12]([CH2:14][CH2:15][C:16]([OH:18])=[O:17])=[O:13])=[CH:10][C:9]=1[O:8][CH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 1

HCID 21450225HCID 21450225, compound

Product 1

HCID 21450248HCID 21450248, compound

Reagents, catalysts & solvents 1

HCID 14923Ammonium HydroxideSolvent2×

Procedure

A solution of 3-(3-benzyloxy-4-nitrobenzoyl)propionic acid in 5N ammonium hydroxide was added to a well stirred boiling aqueous solution of ferrous sulphate. The pH was adjusted to 9 with concentrated ammonium hydroxide and the mixture was refluxed for 15 minutes. The filtrate was concentrated under reduced pressure and then neutralised with glacial acetic acid to give 3-(4-amino-3-benzyloxybenzoyl)propionic acid.

Workup

  1. temperaturethe mixture was refluxed for 15 minutes
  2. concentrationThe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-3ccde1d346364bb8906b70a605608ac7
Source dataset
uspto-grants-1977_03
Patent number
US04011321

Reaction notes

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