Hydrazine hydrate (1:1) → HCID 21450238, compound

HRID 596706Notes

Reaction equation

HRID 596706 reaction equation
[C:1]([NH:5][CH2:6][CH:7]([OH:26])[CH2:8][O:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]2[CH2:17][CH2:18][C:19](=[O:22])[NH:20][N:21]=2)=[CH:12][C:11]=1[N+:23]([O-])=O)([CH3:4])([CH3:3])[CH3:2].O.NN>[Pd].C(O)C>[NH2:23][C:11]1[CH:12]=[C:13]([C:16]2[CH2:17][CH2:18][C:19](=[O:22])[NH:20][N:21]=2)[CH:14]=[CH:15][C:10]=1[O:9][CH2:8][CH:7]([OH:26])[CH2:6][NH:5][C:1]([CH3:4])([CH3:2])[CH3:3]

Participants

5

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 21450279HCID 21450279, compound

Product 1

HCID 21450238HCID 21450238, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

6-[4-(3-t-Butylamino-2-hydroxypropoxy)-3-nitrophenyl]-4,5-dihydro-3(2H)-pyridazinone was reduced over 10% palladium on charcoal with excess hydrazine hydrate in ethanol to give the title compound.

Sources & evidence

ORD record
ord-a47ad9632c744a259a444f292d21a8ef
Source dataset
uspto-grants-1977_03
Patent number
US04011321

Reaction notes

Loading…