Hydrochloric Acid → HCID 20309545, compound

HRID 596707Notes

Reaction equation

HRID 596707 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([O:15][CH2:16][CH:17]([OH:24])[CH2:18][NH:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[C:6]([CH:14]=1)[C:7]([CH2:9][CH2:10][C:11]([OH:13])=[O:12])=[O:8].Cl.[C:26](=O)([O-])[O-].[Na+].[Na+]>CO.O>[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([O:15][CH2:16][CH:17]([OH:24])[CH2:18][NH:19][C:20]([CH3:21])([CH3:23])[CH3:22])=[C:6]([CH:14]=1)[C:7]([CH2:9][CH2:10][C:11]([O:13][CH3:26])=[O:12])=[O:8]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 10340Sodium CarbonateHCID 20309496HCID 20309496, compound

Product 1

HCID 20309545HCID 20309545, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

3-[5-Amino-2-(3-t-butylamino-2-hydroxypropoxy)benzoyl]propionic acid was esterified with hydrogen chloride in methanol. Evaporation of the solution under reduced pressure gave a residue which was dissolved in the minimum of water and the solution was neutralised with sodium carbonate and extracted with dichloromethane. The combined extracts were washed with saturated brine, dried, and evaporated to give methyl 3-[5-amino-2-(3-t-butylamino-2-hydroxypropoxy)benzoyl]propionate.

Workup

  1. customEvaporation of the solution under reduced pressure
  2. customgave a residue which
  3. extractionextracted with dichloromethane
  4. washThe combined extracts were washed with saturated brine
  5. customdried
  6. customevaporated

Sources & evidence

ORD record
ord-8c58f3b943e64b0380472b79bb88672e
Source dataset
uspto-grants-1977_03
Patent number
US04011321

Reaction notes

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