Hydrazine hydrate (1:1) → HCID 20309553, compound

HRID 596708Notes

Reaction equation

HRID 596708 reaction equation
[C:1]([NH:5][CH2:6][CH:7]([OH:25])[CH2:8][O:9][C:10]1[CH:22]=[CH:21][C:20]([NH:23][CH3:24])=[CH:19][C:11]=1[C:12]([CH2:14][CH2:15][C:16](O)=[O:17])=O)([CH3:4])([CH3:3])[CH3:2].O.[NH2:27][NH2:28]>>[C:1]([NH:5][CH2:6][CH:7]([OH:25])[CH2:8][O:9][C:10]1[CH:22]=[CH:21][C:20]([NH:23][CH3:24])=[CH:19][C:11]=1[C:12]1[CH2:14][CH2:15][C:16](=[O:17])[NH:27][N:28]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 20309477HCID 20309477, compound

Product 1

HCID 20309553HCID 20309553, compound

Procedure

By subjecting 3-[2-(3-t-butylamino-2-hydroxypropoxy)-5-(methylamino)benzoyl]propionic acid to cyclisation with hydrazine hydrate by a method similar to that described in Example 19(ix), the title compound may be prepared.

Sources & evidence

ORD record
ord-e4c77dac32da433ab0de7337306d8d63
Source dataset
uspto-grants-1977_03
Patent number
US04011321

Reaction notes

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