Acetyl chloride → HCID 20370071, compound

HRID 596711Notes

Reaction equation

HRID 596711 reaction equation
C(Cl)(=O)C.FC1C=CC(C(C)(C)CC(Cl)=O)=CC=1.[F:19][C:20]1[CH:25]=[CH:24][C:23]([C:26]([CH3:37])([CH3:36])[CH:27]=[C:28]=[C:29]([CH3:35])[C:30]([O:32]CC)=[O:31])=[CH:22][CH:21]=1>>[F:19][C:20]1[CH:21]=[CH:22][C:23]([C:26]([CH3:37])([CH3:36])[CH:27]=[C:28]=[C:29]([CH3:35])[C:30]([OH:32])=[O:31])=[CH:24][CH:25]=1

Participants

4

Reactant 3

HCID 6367Acetyl chlorideHCID 20370062HCID 20370062, compoundHCID 23293596HCID 23293596, compound

Product 1

HCID 20370071HCID 20370071, compound

Procedure

Repeating the procedure of Example 1, step B, but replacing the p-thiomethylphenyl)-acetyl chloride, used therein, with an approximately equivalent amount of 3-(p-fluorophenyl)-3-methyl-butyryl chloride, there is accordingly obtained ethyl 5-(p-fluorophenyl)-2,5-dimethyl-hexa-2,3-dienoate, which upon treatment according to Example 2, yields 5-(p-fluorophenyl)-2,5-dimethyl-hexa-2,3-dienoic acid, m.p. (72.5° - 75.5°).

Sources & evidence

ORD record
ord-e769c9c38846473ab1f8617a480c4346
Source dataset
uspto-grants-1977_03
Patent number
US04011339

Reaction notes

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