2-(Methylamino)acetaldehyde → HCID 21447828, compound

Participants

Reaction Steps

A mixture of 5-(1-methylcyclohexyl)-1,3,4-thiadiazol-2-yl isocyanate dimer (7.5 grams), the dimethyl acetal of 2-methylaminoacetaldehyde (5 grams) and ethyl acetate (50 ml) are charged into a glass reaction vessel equipped with a mechanical stirrer and reflux condenser. The reaction mixture is heated at reflux for a period of about 2 hours. After this time the mixture is stripped of solvent under reduced pressure to yield the desired product the dimethyl acetal of 2-{1-methyl-3[5-(1-methylcyclohexyl)-1,3,4-thiadiazol-2-yl]ureido}acetaldehyde.

Provenance & Evidence