2-(Methylamino)acetaldehyde → HCID 21447828, compound

HRID 596741Notes

Reaction equation

HRID 596741 reaction equation
[CH3:1][C:2]1([C:8]2[S:12][C:11]([N:13]=[C:14]=[O:15])=[N:10][N:9]=2)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1.[CH3:16][NH:17][CH2:18][CH:19]=[O:20]>C(OCC)(=O)C>[CH3:16][N:17]([CH2:18][CH:19]=[O:20])[C:14]([NH:13][C:11]1[S:12][C:8]([C:2]2([CH3:1])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7]2)=[N:9][N:10]=1)=[O:15]

Participants

4

Reactant 2

HCID 133161322-(Methylamino)acetaldehydeHCID 54118858HCID 54118858, compound

Product 1

HCID 21447828HCID 21447828, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A mixture of 5-(1-methylcyclohexyl)-1,3,4-thiadiazol-2-yl isocyanate dimer (7.5 grams), the dimethyl acetal of 2-methylaminoacetaldehyde (5 grams) and ethyl acetate (50 ml) are charged into a glass reaction vessel equipped with a mechanical stirrer and reflux condenser. The reaction mixture is heated at reflux for a period of about 2 hours. After this time the mixture is stripped of solvent under reduced pressure to yield the desired product the dimethyl acetal of 2-{1-methyl-3[5-(1-methylcyclohexyl)-1,3,4-thiadiazol-2-yl]ureido}acetaldehyde.

Workup

  1. customequipped with a mechanical stirrer
  2. temperaturereflux condenser
  3. temperatureThe reaction mixture is heated
  4. temperatureat reflux for a period of about 2 hours

Sources & evidence

ORD record
ord-5a45146ffa3443ab974ead69f5074118
Source dataset
uspto-grants-1977_03
Patent number
US04012223

Reaction notes

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