Ethylamine → HCID 12284406, compound

HRID 596794Notes

Reaction equation

HRID 596794 reaction equation
[CH3:1][N:2]1[CH:7]=[C:6]([C:8]2[CH:9]=[C:10]([C:14]([F:17])([F:16])[F:15])[CH:11]=[CH:12][CH:13]=2)[C:5](=[O:18])[N:4]=[CH:3]1.[CH2:19](N)C>CO>[CH2:1]([N:2]1[CH:7]=[C:6]([C:8]2[CH:9]=[C:10]([C:14]([F:15])([F:17])[F:16])[CH:11]=[CH:12][CH:13]=2)[C:5](=[O:18])[N:4]=[CH:3]1)[CH3:19]

Participants

4

Reactant 2

HCID 6341EthylamineHCID 12284402HCID 12284402, compound

Product 1

HCID 12284406HCID 12284406, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Two g. of the intermediate atropamide of Example 2 was reacted with 1 cc. of 20 percent aqueous ethylamine in 20 ml. of methanol. The reaction mixture was stirred at reflux temperature for 6 hours and evaporated to dryness, and the residue was recrystallized from ethyl acetatehexane. The product was 1.3 g. of 1-ethyl-5-(α,α,α-trifluoro-m-tolyl)-4(1H)-pyrimidinone, m.p. 172°-173° C.

Workup

  1. temperatureat reflux temperature for 6 hours
  2. customevaporated to dryness
  3. customthe residue was recrystallized from ethyl acetatehexane

Sources & evidence

ORD record
ord-90c1838459654ed4931fbbf3ec2e23b8
Source dataset
uspto-grants-1977_03
Patent number
US04012388

Reaction notes

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