Ethylamine → HCID 12284406, compound

Participants

Reaction Steps

Two g. of the intermediate atropamide of Example 2 was reacted with 1 cc. of 20 percent aqueous ethylamine in 20 ml. of methanol. The reaction mixture was stirred at reflux temperature for 6 hours and evaporated to dryness, and the residue was recrystallized from ethyl acetatehexane. The product was 1.3 g. of 1-ethyl-5-(α,α,α-trifluoro-m-tolyl)-4(1H)-pyrimidinone, m.p. 172°-173° C.

Provenance & Evidence