Trifluoroacetic acid → HCID 22796388, compound

HRID 596806Notes

Reaction equation

HRID 596806 reaction equation
C(OC([NH:8][C@H:9]([C:20]([NH:22][C@H:23]([C:28]([NH:30][C@H:31]([C:36]([NH:38][CH:39]([C:44]([NH2:46])=[O:45])[CH2:40][CH2:41][CH2:42][CH3:43])=[O:37])[CH2:32][C:33](=[O:35])[OH:34])=[O:29])[CH2:24][CH2:25][S:26][CH3:27])=[O:21])[CH2:10][C:11]1[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[NH:13][CH:12]=1)=O)(C)(C)C.[F:47][C:48]([F:53])([F:52])[C:49]([OH:51])=[O:50]>O1CCOCC1>[F:47][C:48]([F:53])([F:52])[C:49]([OH:51])=[O:50].[NH2:8][C@H:9]([C:20]([NH:22][C@H:23]([C:28]([NH:30][C@H:31]([C:36]([NH:38][CH:39]([C:44]([NH2:46])=[O:45])[CH2:40][CH2:41][CH2:42][CH3:43])=[O:37])[CH2:32][C:33](=[O:34])[OH:35])=[O:29])[CH2:24][CH2:25][S:26][CH3:27])=[O:21])[CH2:10][C:11]1[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[NH:13][CH:12]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 22796336HCID 22796336, compound

Product 1

HCID 22796388HCID 22796388, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

the reaction of N-t-butoxycarbonyl-L-tryptophanyl-L-methionyl-L-aspartyl-DL-norleucine amide according to the procedure of Example 7 using trifluoroacetic acid instead of hydrochloric acid in dioxane affords L-tryptophanyl-L-methionyl-L-aspartyl-DL-norleucine amide trifluoroacetate. This compound is represented by the following formula.

Sources & evidence

ORD record
ord-b04bf27eb9264ac38914a5356d4303ba
Source dataset
uspto-grants-1977_03
Patent number
US04012367

Reaction notes

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