HRID596809

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID260

Hydrogen Bromide

BrH

结构：CCCC(NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1)C(N)=O

HCID22796407

未命名化合物

PRODUCTS

生成物

结构：Br.CCCC(NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(N)=O

HCID22796390

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID176

Acetic Acid

C2H4O2

2 次

溶剂HCID12230

Ethyl methyl sulfide

C3H8S

PROCEDURE

实验过程

N-benzyloxycarbonyl-L-tryptophanyl-L-methionyl-L-aspartyl-DL-norvaline amide is dissolved in 10 parts glacial acetic acid containing 2 parts methylethyl sulfide. Then, 10 parts of 6 M hydrobromic acid in acetic acid is added and the solution is allowed to stand for one hour at room temperature. The solvents are removed under vacuum below 40° C. and the residue shaken with ether to afford L-tryptophanyl-L-methionyl-L-aspartyl-DL-norvaline amide hydrobromide. This compound is represented by the following formula.

WORKUP

后处理

customThe solvents are removed under vacuum below 40° C.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-8ac2eeb5e3e447358b5e3ac14dbce5f5
来源数据集: uspto-grants-1977_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04012367
来源说明: uspto-grants-1977_03

反应 SMILES

C(OC([NH:11][C@H:12]([C:23]([NH:25][C@H:26]([C:31]([NH:33][C@H:34]([C:39]([NH:41][CH:42]([C:46]([NH2:48])=[O:47])[CH2:43][CH2:44][CH3:45])=[O:40])[CH2:35][C:36](=[O:38])[OH:37])=[O:32])[CH2:27][CH2:28][S:29][CH3:30])=[O:24])[CH2:13][C:14]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[NH:16][CH:15]=1)=O)C1C=CC=CC=1.[BrH:49]>C(O)(=O)C.CSCC>[BrH:49].[NH2:11][C@H:12]([C:23]([NH:25][C@H:26]([C:31]([NH:33][C@H:34]([C:39]([NH:41][CH:42]([C:46]([NH2:48])=[O:47])[CH2:43][CH2:44][CH3:45])=[O:40])[CH2:35][C:36](=[O:37])[OH:38])=[O:32])[CH2:27][CH2:28][S:29][CH3:30])=[O:24])[CH2:13][C:14]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[NH:16][CH:15]=1