HCID 54246754, compound → HCID 7128961, compound

HRID 596811Notes

Reaction equation

HRID 596811 reaction equation
[CH2:1]([NH:4][C:5](=[O:19])[C@@H:6]([CH3:18])[NH:7]C(OCC1C=CC=CC=1)=O)[CH2:2][CH3:3].[H][H]>C(O)C.[Pd]>[CH2:1]([NH:4][C:5](=[O:19])[C@@H:6]([CH3:18])[NH2:7])[CH2:2][CH3:3]

Participants

5

Reactant 2

HCID 54246754HCID 54246754, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 7128961HCID 7128961, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

35.0 Parts of benzyloxycarbonyl-D-alanine n-propylamide is dissolved in ethanol. Then, palladium black catalyst is added and the mixture is shaken at about 60 psi at room temperature for several hours or until one molecular equivalent of hydrogen has been absorbed. The catalyst is removed by filtration, and the resulting solution is decolorized with charcoal. Removal of the solvents under reduced pressure affords, as an oil, D-alanine n-propylamide.

Workup

  1. customhas been absorbed
  2. customThe catalyst is removed by filtration
  3. customRemoval of the solvents under reduced pressure

Sources & evidence

ORD record
ord-ef8f15da04a048359d7e23197ea54959
Source dataset
uspto-grants-1977_03
Patent number
US04012367

Reaction notes

Loading…