HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetone → 1-(3',4'-Dichloro benzyl)-2-phenyl-3-keto piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetone | HCID 180 | — |
| Reactant | 3,4-Dichlorobenzyl chloride | HCID 7609 | — |
| Reactant | 3-Phenylpiperazin-2-one | HCID 250681 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | 1-(3',4'-Dichloro benzyl)-2-phenyl-3-keto piperazine | HCID 21448578 | — |
Reaction Steps
140 g. of 2-phenyl-3-keto piperazine are boiled under reflux with 163 g. of 3,4-dichloro benzylchloride in 1,600 cc. of acetone for 6 hours while 330 cc. of triethylamine are added. The hot reaction mixture is filtered to remove precipitated triethyl ammonium chloride and is concentrated by fractional distillation. The resulting crystal fractions are twice recrystallized from 4 l. of 96% ethanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04012389 |
| Source dataset | uspto-grants-1977_03 |
| ORD ID | ord-d196eda915bf49baa0a8c8d7490173b9 |
| Source note | uspto-grants-1977_03 |