反应详情

140 g. of 2-phenyl-3-keto piperazine are boiled under reflux with 163 g. of 3,4-dichloro benzylchloride in 1,600 cc. of acetone for 6 hours while 330 cc. of triethylamine are added. The hot reaction mixture is filtered to remove precipitated triethyl ammonium chloride and is concentrated by fractional distillation. The resulting crystal fractions are twice recrystallized from 4 l. of 96% ethanol.

1. temperatureunder reflux with 163 g
2. filtrationThe hot reaction mixture is filtered
3. customto remove
4. customprecipitated triethyl ammonium chloride
5. concentrationis concentrated by fractional distillation
6. customThe resulting crystal fractions are twice recrystallized from 4 l