1-(3',4',5'-Trimethoxy benzyl)-2-phenyl-3-keto piperazine → 1-(3',4',5'-Trimethoxy benzyl)-2-phenyl piperazine

HRID 596857Notes

Reaction equation

HRID 596857 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:20]=[C:21]([O:25][CH3:26])[C:22]=1[O:23][CH3:24])[CH2:6][N:7]1[CH2:12][CH2:11][NH:10][C:9](=O)[CH:8]1[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.C(N(CC)C(N1CCNC(=O)C1C1C=CC=CC=1)C)C>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:20]=[C:21]([O:25][CH3:26])[C:22]=1[O:23][CH3:24])[CH2:6][N:7]1[CH2:12][CH2:11][NH:10][CH2:9][CH:8]1[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

Participants

3

Reactant 2

HCID 214485341-(3',4',5'-Trimethoxy benzyl)-2-phenyl-3-keto piperazineHCID 214485351-Diethylamino ethyl-2-phenyl-3-keto piperazine

Product 1

HCID 214485551-(3',4',5'-Trimethoxy benzyl)-2-phenyl piperazine

Procedure

1-(3',4',5'-Trimethoxy benzyl)-2-phenyl-3-keto piperazine prepared according to Example 13, is reduced by following the procedure described hereinabove in Example 8 (a) whereby, in place of 1-diethylamino ethyl-3-keto-2-phenyl piperazine, the equimolecular amount of said 1-(3',4',5'-trimethoxy benzyl-2-phenyl-3-keto piperazine is used. The resulting 2-phenyl piperazine compound is obtained in the form of a yellow oil boiling at 185-195° C./0.08 mm. Hg.

Sources & evidence

ORD record
ord-28366af579414bc0b9556f9d33338835
Source dataset
uspto-grants-1977_03
Patent number
US04012389

Reaction notes

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