Diethylamine → 1-(4'-Chloro benzyl)-2-phenyl-4-(diethylaminoethyl) piperazine

HRID 596864Notes

Reaction equation

HRID 596864 reaction equation
Cl.[Cl:2][C:3]1[CH:24]=[CH:23][C:6]([CH2:7][N:8]2[CH2:13][CH2:12][N:11]([CH2:14][CH2:15]Cl)[CH2:10][CH:9]2[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[CH:5][CH:4]=1.[CH2:25]([NH:27][CH2:28][CH3:29])[CH3:26]>CC(C)=O>[Cl:2][C:3]1[CH:24]=[CH:23][C:6]([CH2:7][N:8]2[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][N:27]([CH2:28][CH3:29])[CH2:25][CH3:26])[CH2:10][CH:9]2[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 8021DiethylamineHCID 70638444HCID 70638444, compound

Product 1

HCID 545399441-(4'-Chloro benzyl)-2-phenyl-4-(diethylaminoethyl) piperazine

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

20 g. of 1-(4'-chloro benzyl)-2-phenyl-4-(β-chloro ethyl) piperazine hydrochloride, 14 g. of diethylamine and 200 cc. of acetone are boiled under reflux for 12 hours. After cooling, the precipitated diethylamino hydrochloride is filtered off with suction and the solvent of the filtrate is evaporated in a vacuum. The residue is distilled in a vacuum. 15 g. of a light yellow oil having a boiling point of 190° C./0.06 mm. Hg are obtained. This product is identical with the product as obtained according to Example 1 B.

Workup

  1. temperatureunder reflux for 12 hours
  2. temperatureAfter cooling
  3. filtrationthe precipitated diethylamino hydrochloride is filtered off with suction
  4. customthe solvent of the filtrate is evaporated in a vacuum
  5. distillationThe residue is distilled in a vacuum
  6. customare obtained
  7. customas obtained

Sources & evidence

ORD record
ord-da61dc8e8f124045a71d8124226ba79b
Source dataset
uspto-grants-1977_03
Patent number
US04012389

Reaction notes

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