反应详情

20 g. of 1-(4'-chloro benzyl)-2-phenyl-4-(β-chloro ethyl) piperazine hydrochloride, 14 g. of diethylamine and 200 cc. of acetone are boiled under reflux for 12 hours. After cooling, the precipitated diethylamino hydrochloride is filtered off with suction and the solvent of the filtrate is evaporated in a vacuum. The residue is distilled in a vacuum. 15 g. of a light yellow oil having a boiling point of 190° C./0.06 mm. Hg are obtained. This product is identical with the product as obtained according to Example 1 B.

1. temperatureunder reflux for 12 hours
2. temperatureAfter cooling
3. filtrationthe precipitated diethylamino hydrochloride is filtered off with suction
4. customthe solvent of the filtrate is evaporated in a vacuum
5. distillationThe residue is distilled in a vacuum
6. customare obtained
7. customas obtained