4-Ethinyl-2-(p-methoxybenzyl)-1,3,3-trimethyl-4-piperidinol → 4-Ethyl-2-(p-methoxybenzyl)-1,3,3-trimethyl-4-piperidinol

HRID 596877Notes

Reaction equation

HRID 596877 reaction equation
[C:1]([C:3]1([OH:21])[CH2:8][CH2:7][N:6]([CH3:9])[CH:5]([CH2:10][C:11]2[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=2)[C:4]1([CH3:20])[CH3:19])#[CH:2]>CO.[Pd]>[CH2:1]([C:3]1([OH:21])[CH2:8][CH2:7][N:6]([CH3:9])[CH:5]([CH2:10][C:11]2[CH:12]=[CH:13][C:14]([O:17][CH3:18])=[CH:15][CH:16]=2)[C:4]1([CH3:20])[CH3:19])[CH3:2]

Participants

4

Reactant 1

HCID 214486184-Ethinyl-2-(p-methoxybenzyl)-1,3,3-trimethyl-4-piperidinol

Product 1

HCID 167261404-Ethyl-2-(p-methoxybenzyl)-1,3,3-trimethyl-4-piperidinol

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of 56 g of 4-ethinyl-2-(p-methoxybenzyl)-1,3,3-trimethyl-4-piperidinol in 350 ml of methanol is subjected to hydrogenation at atmospheric pressure and room temperature, the catalyst being 5% palladium on charcoal (5 g.).

Workup

  1. customis subjected to hydrogenation at atmospheric pressure and room temperature

Sources & evidence

ORD record
ord-a8869df48025470881be001b8a49e896
Source dataset
uspto-grants-1977_03
Patent number
US04012392

Reaction notes

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