HCID 12369008, compound → HCID 12369024, compound

HRID 596990Notes

Reaction equation

HRID 596990 reaction equation
C([N:8]([CH2:13][CH:14]([OH:34])[C:15]1[CH:20]=[CH:19][C:18]([O:21]CC2C=CC=CC=2)=[C:17]([CH:29]([O:32][CH3:33])[CH2:30][OH:31])[CH:16]=1)[C:9]([CH3:12])([CH3:11])[CH3:10])C1C=CC=CC=1>[Pd].C(O)C>[C:9]([NH:8][CH2:13][CH:14]([OH:34])[C:15]1[CH:20]=[CH:19][C:18]([OH:21])=[C:17]([CH:29]([O:32][CH3:33])[CH2:30][OH:31])[CH:16]=1)([CH3:12])([CH3:11])[CH3:10]

Participants

4

Reactant 1

HCID 12369008HCID 12369008, compound

Product 1

HCID 12369024HCID 12369024, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

The benzyl alcohol (0.7 g., 1.5 mmol) in 150 ml. of ethanol is hydrogenated over 0.7 g. of 10% palladium-on-carbon at 50 psi for 25 minutes. The catalyst is filtered and the filtrate evaporated to give α-(t-butylaminomethyl)-4-hydroxy-3-(2-hydroxy-1-methoxyethyl)-benzyl alcohol; fumarate m.p. 230° C. (decomp.).

Workup

  1. filtrationThe catalyst is filtered
  2. customthe filtrate evaporated

Sources & evidence

ORD record
ord-e4649289cea24b26b4c1c17896ca87e7
Source dataset
uspto-grants-1977_03
Patent number
US04012528

Reaction notes

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