反应详情

Potassium tert-butoxide (1.68 g., 0.015 mole) in dry tert-butyl alcohol (40 ml.) is added to a refluxing solution of 2methyl-5-methoxy-6,7-dichloro-1indanone in benzene (50 ml.). After refluxing for 30 minutes, benzyl bromide (1.72 g., 0.01 mole) in benzene (10 ml.) is added dropwise. After refluxing for an additional 30 minutes the mixture is cooled, water (10 ml.) is added and the mixture is evaporated to dryness. The residue is washed with water and taken up with ether. The ether solution is washed with water and a saturated sodium chloride solution, dried over sodium sulfate and evaporated. The syrupy residue of 2-benzyl-2-methyl-5-methoxy-6,7-dichloro-1-indanone (3 g.) is used directly in the next step without purification.

1. temperatureAfter refluxing for 30 minutes
2. temperatureAfter refluxing for an additional 30 minutes the mixture
3. temperatureis cooled
4. customthe mixture is evaporated to dryness
5. washThe residue is washed with water
6. washThe ether solution is washed with water
7. dry with materiala saturated sodium chloride solution, dried over sodium sulfate
8. customevaporated
9. customThe syrupy residue of 2-benzyl-2-methyl-5-methoxy-6,7-dichloro-1-indanone (3 g.) is used directly in the next step without purification