Formaldehyde → 2',3'-Dichloro-4'-methylthio-2-cyclopentylacrylophenone

HRID 597023Notes

Reaction equation

HRID 597023 reaction equation
[Cl:1][C:2]1[C:7]([Cl:8])=[C:6]([S:9][CH3:10])[CH:5]=[CH:4][C:3]=1[C:11](=[O:18])[CH2:12][CH:13]1[CH2:17][CH2:16][CH2:15][CH2:14]1.[CH2:19]=O.S(=O)(=O)(O)O>O1CCOCC1>[Cl:1][C:2]1[C:7]([Cl:8])=[C:6]([S:9][CH3:10])[CH:5]=[CH:4][C:3]=1[C:11](=[O:18])[C:12]([CH:13]1[CH2:14][CH2:15][CH2:16][CH2:17]1)=[CH2:19]

Participants

5

Reactant 3

HCID 712FormaldehydeHCID 1118Sulfuric AcidHCID 203584462',3'-Dichloro-4'-methylthio-2-cyclopentylacetophenone

Product 1

HCID 203584602',3'-Dichloro-4'-methylthio-2-cyclopentylacrylophenone

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

2',3'-dichloro-4'-methylthio-2-cyclopentylacrylophenone is prepared following substantially the same procedure described in Example 3, Step B, using the following substances: 2',3'-dichloro-4'-methylthio-2-cyclopentylacetophenone (54.5 g., 0.18 mole), paraformaldehyde (21.6 g., 0.72 mole), concentrated sulfuric acid (9.65 g.) and dioxane (450 ml.).

Sources & evidence

ORD record
ord-8b9de3dec3c8441a867aa0d9fc4dc098
Source dataset
uspto-grants-1977_03
Patent number
US04012524

Reaction notes

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