Sodium Hydroxide → HCID 131710682, compound

HRID 597046Notes

Reaction equation

HRID 597046 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[N:8]([C:12]1[C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[N:15]=[C:14]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[CH:13]=1)[C:7]([CH3:28])=[C:6]2[CH2:29][C:30]([O:32]CC)=[O:31].[OH-].[Na+:36]>C(O)C>[OH2:2].[Na+:36].[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[N:8]([C:12]1[C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[N:15]=[C:14]([C:22]3[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=3)[CH:13]=1)[C:7]([CH3:28])=[C:6]2[CH2:29][C:30]([O-:32])=[O:31]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 131710684HCID 131710684, compound

Product 1

HCID 131710682HCID 131710682, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Ethyl 5-methoxy-2-methyl-1-(2-phenylquinol-4-yl)indol-3-ylacetate (2.1g.) in ethanol (20ml.) and 2N-sodium hydroxide solution (20ml.) was refluxed for 0.25 hour. Most of the ethanol was removed in vacuo and the residue was diluted with water (50ml.). The resulting mixture was filtered, and the residue was washed with water and dried at 60° C. to give 5-methoxy-2-methyl-1-(2-phenylquinol-4-yl)indol-3-ylacetic acid sodium salt monohydrate, m.p. 179°-180° C.

Workup

  1. customMost of the ethanol was removed in vacuo
  2. additionthe residue was diluted with water (50ml.)
  3. filtrationThe resulting mixture was filtered
  4. washthe residue was washed with water
  5. customdried at 60° C.

Sources & evidence

ORD record
ord-d33a04eee10542f4b31e75fb71dbb77a
Source dataset
uspto-grants-1977_03
Patent number
US04012513

Reaction notes

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