Dimethylamine → HCID 21449025, compound

HRID 597073Notes

Reaction equation

COC(=O)[CH2:4][C:5]1[N:9]2[C:10]3[CH:26]=[CH:25][CH:24]=[CH:23][C:11]=3[C:12]([C:15]3(Cl)[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]3[Cl:21])=[N:13][CH2:14][C:8]2=[N:7][N:6]=1.CNC.[CH3:31][N:32]([CH3:35])[CH:33]=[O:34]>>[CH3:31][N:32]([CH3:35])[C:33](=[O:34])[CH2:4][C:5]1[N:9]2[C:10]3[CH:26]=[CH:25][CH:24]=[CH:23][C:11]=3[C:12]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=3[Cl:21])=[N:13][CH2:14][C:8]2=[N:7][N:6]=1

Participants

Reactant 3

HCID 674Dimethylamine

HCID 6228Dimethylformamide

HCID 86734563HCID 86734563, compound

Product 1

HCID 21449025HCID 21449025, compound

Procedure

In the manner given in Preparation 3, 6-(o-dichlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine-1-acetic acid methyl ester is reacted with dimethylamine in dimethyl formamide to give N,N-dimethyl-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine-1-acetamide.

Sources & evidence

ORD record: ord-26aa606a01694fc58edb3e9026c19956
Source dataset: uspto-grants-1977_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04012413

Reaction notes

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