Methylamine → HCID 21448993, compound

HRID 597074Notes

Reaction equation

C[O:2][C:3](=O)[CH2:4][C:5]1[N:9]2[C:10]3[CH:27]=[CH:26][C:25]([C:28]([F:31])([F:30])[F:29])=[C:24]([Br:32])[C:11]=3[C:12]([C:15]3[CH:20]=[CH:19][CH:18]=[C:17]([N+:21]([O-:23])=[O:22])[CH:16]=3)=[N:13][CH2:14][C:8]2=[N:7][N:6]=1.[CH3:34][NH2:35]>>[CH3:34][NH:35][C:3](=[O:2])[CH2:4][C:5]1[N:9]2[C:10]3[CH:27]=[CH:26][C:25]([C:28]([F:29])([F:30])[F:31])=[C:24]([Br:32])[C:11]=3[C:12]([C:15]3[CH:20]=[CH:19][CH:18]=[C:17]([N+:21]([O-:23])=[O:22])[CH:16]=3)=[N:13][CH2:14][C:8]2=[N:7][N:6]=1

Participants

Reactant 2

HCID 6329Methylamine

HCID 86734565HCID 86734565, compound

Product 1

HCID 21448993HCID 21448993, compound

Procedure

In the manner given in Preparation 3, 7-bromo-8-trifluoromethyl-6-(m-nitrophenyl)-4H-s-triazolo[4,3-a][1,4]-benzodiazepine-1-acetic acid methyl ester is reacted with methylamine in diemethylformamide to give N-methyl-7-bromo-8-trifluoromethyl-6-(m-nitrophenyl)-4H-s-triazolo[4,3-a]-[1,4]benzodiazepine-1-acetamide.

Sources & evidence

ORD record: ord-d0b30b8fb5d448d9b45afe718cd0be9c
Source dataset: uspto-grants-1977_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04012413

Reaction notes

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