1,1'-Carbonyldiimidazole → 3-phthalimidovaleric acid, 2-(7-nitro-5-(o-chlorophenyl)-3H-1,4-benzodiazepin-2-yl)hydrazide

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Reaction Steps

In the manner given in Example 20, 3-phthalimidovaleric acid and carbonyldiimidazol are reacted in tetrahydrofuran. To this mixture is added 7-nitro-2-hydrazino-5-(o-chlorophenyl)-3H-1,4-benzodiazepine to give 3-phthalimidovaleric acid, 2-(7-nitro-5-(o-chlorophenyl)-3H-1,4-benzodiazepin-2-yl)hydrazide which is warmed with acetic acid to give N-[2-[8-nitro-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepin-1-yl]butyl]phthalimide.

Provenance & Evidence