HRID597085

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID68263

1,1'-Carbonylbis(1H-imidazole)

C7H6N4O

结构：NNC1=Nc2ccc([N+](=O)[O-])cc2C(c2ccccc2Cl)=NC1

HCID20291856

未命名化合物

HCID21448998

未命名化合物

PRODUCTS

生成物

结构：CCC(CC(=O)NNC1=Nc2ccc([N+](=O)[O-])cc2C(c2ccccc2Cl)=NC1)N1C(=O)c2ccccc2C1=O

HCID86734567

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

In the manner given in Example 20, 3-phthalimidovaleric acid and carbonyldiimidazol are reacted in tetrahydrofuran. To this mixture is added 7-nitro-2-hydrazino-5-(o-chlorophenyl)-3H-1,4-benzodiazepine to give 3-phthalimidovaleric acid, 2-(7-nitro-5-(o-chlorophenyl)-3H-1,4-benzodiazepin-2-yl)hydrazide which is warmed with acetic acid to give N-[2-[8-nitro-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepin-1-yl]butyl]phthalimide.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-512f0bd8a27741a591c49e2461767217
来源数据集: uspto-grants-1977_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04012413
来源说明: uspto-grants-1977_03

反应 SMILES

[C:1]1(=[O:18])[N:5]([CH:6]([CH2:11][CH3:12])[CH2:7][C:8]([OH:10])=O)[C:4](=[O:13])[C:3]2=[CH:14][CH:15]=[CH:16][CH:17]=[C:2]12.C(N1C=CN=C1)(N1C=CN=C1)=O.[N+:31]([C:34]1[CH:35]=[CH:36][C:37]2[N:43]=[C:42]([NH:44][NH2:45])[CH2:41][N:40]=[C:39]([C:46]3[CH:51]=[CH:50][CH:49]=[CH:48][C:47]=3[Cl:52])[C:38]=2[CH:53]=1)([O-:33])=[O:32]>O1CCCC1>[N+:31]([C:34]1[CH:35]=[CH:36][C:37]2[N:43]=[C:42]([NH:44][NH:45][C:8](=[O:10])[CH2:7][CH:6]([N:5]3[C:1](=[O:18])[C:2]4=[CH:17][CH:16]=[CH:15][CH:14]=[C:3]4[C:4]3=[O:13])[CH2:11][CH3:12])[CH2:41][N:40]=[C:39]([C:46]3[CH:51]=[CH:50][CH:49]=[CH:48][C:47]=3[Cl:52])[C:38]=2[CH:53]=1)([O-:33])=[O:32]