Ethanol → HCID 21449058, compound

HRID 597086Notes

Reaction equation

HRID 597086 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]3[C:12]([CH:15](C)[CH2:16][N:17]4C(=O)C5=CC=CC=C5C4=O)=[N:13][N:14]=[C:10]3[CH2:9][N:8]=[C:7]([C:29]3[C:34]([F:35])=[CH:33][CH:32]=[CH:31][C:30]=3[F:36])[C:6]=2[CH:37]=1.O.NN.[CH2:41](O)C>>[NH2:17][CH:16]([CH3:41])[CH2:15][C:12]1[N:11]2[C:5]3[CH:4]=[CH:3][C:2]([Cl:1])=[CH:37][C:6]=3[C:7]([C:29]3[C:30]([F:36])=[CH:31][CH:32]=[CH:33][C:34]=3[F:35])=[N:8][CH2:9][C:10]2=[N:14][N:13]=1

Participants

4

Reactant 3

HCID 702EthanolHCID 24654Hydrazine hydrate (1:1)HCID 21449030HCID 21449030, compound

Product 1

HCID 21449058HCID 21449058, compound

Procedure

In the manner given in Example 21, a solution of N-[2-[8-chloro-6-(2,6-difluorophenyl)-4H-s-triazolo[4,3-a]-[1,4]benzodiazepin-1-yl]propyl]phthalimide in ethanol is heated with hydrazine hydrate to give 1-(2-aminopropyl)-8-chloro-6-(2,6-difluorophenyl)-4H-s-triazolo[4,3-a][1,4]-benzodiazepine.

Sources & evidence

ORD record
ord-383ef977f88a41168188fc780d570636
Source dataset
uspto-grants-1977_03
Patent number
US04012413

Reaction notes

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