Hydrazine hydrate (1:1) → 1-(2-aminoethyl)-8-chloro-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine

HRID 597087Notes

Reaction equation

HRID 597087 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]3[C:12]([CH2:15][CH2:16][N:17]4C(=O)C5=CC=CC=C5C4=O)=[N:13][N:14]=[C:10]3[CH2:9][N:8]=[C:7]([C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=3[Cl:34])[C:6]=2[CH:35]=1.O.NN>>[NH2:17][CH2:16][CH2:15][C:12]1[N:11]2[C:5]3[CH:4]=[CH:3][C:2]([Cl:1])=[CH:35][C:6]=3[C:7]([C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=3[Cl:34])=[N:8][CH2:9][C:10]2=[N:14][N:13]=1

Participants

3

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 126123968-chloro-1-(2-phthalimidoethyl)-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine

Product 1

HCID 126124071-(2-aminoethyl)-8-chloro-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine

Procedure

In the manner given in Example 21, a mixture of N-[2-[8-chloro-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepin-1-yl]ethyl]phthalimide is heated with hydrazine hydrate to give 1-(2-aminoethyl)-8 -chloro-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4] benzodiazepin.

Sources & evidence

ORD record
ord-8aa12d2ffdea4913a3176fe839326411
Source dataset
uspto-grants-1977_03
Patent number
US04012413

Reaction notes

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