Ethanol → HCID 21449011, compound

HRID 597090Notes

Reaction equation

HRID 597090 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]3[C:12]([CH:15](C)CN4C(=O)C5=CC=CC=C5C4=O)=[N:13][N:14]=[C:10]3[CH2:9][N:8]=[C:7]([C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=3[F:35])[C:6]=2[CH:36]=1.O.[NH2:38]N.[CH2:40](O)[CH3:41]>>[NH2:38][CH:40]([CH3:41])[CH2:15][C:12]1[N:11]2[C:5]3[CH:4]=[CH:3][C:2]([Cl:1])=[CH:36][C:6]=3[C:7]([C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=3[F:35])=[N:8][CH2:9][C:10]2=[N:14][N:13]=1

Participants

4

Reactant 3

HCID 702EthanolHCID 24654Hydrazine hydrate (1:1)HCID 21448995HCID 21448995, compound

Product 1

HCID 21449011HCID 21449011, compound

Procedure

In the manner given in Example 21, a solution of N-[2-[8-chloro-6-(o-fluorophenyl)-4H-s-triazolo[4,3-a][1,4]-benzodiazepin-1-yl]propyl]phthalimide in ethanol is heated with hydrazine hydrate to give 1-(2-aminopropyl)-8-chloro-6-(o-fluorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine.

Sources & evidence

ORD record
ord-6609c59d2b5c40f0914e76a7aa6d279d
Source dataset
uspto-grants-1977_03
Patent number
US04012413

Reaction notes

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