Ethanol → HCID 21449010, compound

HRID 597092Notes

Reaction equation

HRID 597092 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]3[C:12]([CH:15](CC)[CH2:16][N:17]4C(=O)C5=CC=CC=C5C4=O)=[N:13][N:14]=[C:10]3[CH2:9][N:8]=[C:7]([C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=3)[C:6]=2[CH:36]=1.O.NN.[CH2:40](O)[CH3:41]>>[NH2:17][CH:16]([CH2:40][CH3:41])[CH2:15][C:12]1[N:11]2[C:5]3[CH:4]=[CH:3][C:2]([Cl:1])=[CH:36][C:6]=3[C:7]([C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=3)=[N:8][CH2:9][C:10]2=[N:14][N:13]=1

Participants

4

Reactant 3

HCID 702EthanolHCID 24654Hydrazine hydrate (1:1)HCID 21449007HCID 21449007, compound

Product 1

HCID 21449010HCID 21449010, compound

Procedure

In the manner given in Example 21, N-[2-(8-chloro-6-phenyl-4H-s-triazolo[4,3-a][ 1,4]benzodiazepin-1-yl)butyl]-phthalimide in ethanol is warmed with hydrazine hydrate to give 1-(2-aminobutyl)-8-chloro-6-phenyl-4H-s-triazolo[4,3-a]-[1,4]benzodiazepine.

Sources & evidence

ORD record
ord-87dcddc038b54a97a6c33d4d0d91a7aa
Source dataset
uspto-grants-1977_03
Patent number
US04012413

Reaction notes

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