Borane → HCID 21449050, compound

HRID 597093Notes

Reaction equation

HRID 597093 reaction equation
[NH2:1][CH:2]([CH3:25])[CH2:3][C:4]1[N:8]2[C:9]3[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][C:10]=3[C:11]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)=[N:12][CH2:13][C:7]2=[N:6][N:5]=1.B>O1CCCC1>[NH2:1][CH:2]([CH3:25])[CH2:3][C:4]1[N:8]2[C:9]3[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][C:10]=3[CH:11]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[NH:12][CH2:13][C:7]2=[N:6][N:5]=1

Participants

4

Reactant 2

HCID 6331BoraneHCID 12612405HCID 12612405, compound

Product 1

HCID 21449050HCID 21449050, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In the manner given in Example 23 a mixture of 1-(2-aminopropyl)-8-chloro-6-phenyl-4H-s-triazolo[4,3-a][1,4]-benzodiazepine and tetrahydrofuran was treated with borane to give 1-(2-aminopropyl)-8-chloro-5,6-dihydro-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine.

Sources & evidence

ORD record
ord-c43501de3a1c4b0086ccac316772f3e8
Source dataset
uspto-grants-1977_03
Patent number
US04012413

Reaction notes

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