HRID597202

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID713

Formamide

CH3NO

HCID13361799

1,2,3,4-Tetrahydroisoquinolin-6-ol--hydrogen bromide (1/1)

C9H12BrNO

PRODUCTS

生成物

HCID21447038

6-Hydroxy-3,4-dihydroisoquinoline-2(1H)-carbaldehyde

C10H11NO2

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID962

Water

H2O

CONDITIONS

反应条件

温度: 100 °C

PROCEDURE

实验过程

46.0 g of 1,2,3,4-tetrahydro-6-hydroxy-isoquinoline-hydrobromide are reacted with 85 ml of formamide for 1 hour at 140° C. with stirring. After cooling to 100° C., 216 ml of water are added, whereby the reaction product crystallizes. 34.0 g of 2-formyl-1,2,3,4-tetrahydro-6-hydroxy-isoquinoline are obtained. m.p. = 185.5° - 186° C. (ethanol).

WORKUP

后处理

customwhereby the reaction product crystallizes