HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 597202Generated: October 30, 2026
Formamide → 6-Hydroxy-3,4-dihydroisoquinoline-2(1H)-carbaldehyde
https://huagongshe.com/reaction/597202
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Formamide | HCID 713 | — |
| Reactant | 1,2,3,4-Tetrahydroisoquinolin-6-ol--hydrogen bromide (1/1) | HCID 13361799 | — |
| Solvent | Water | HCID 962 | — |
| Product | 6-Hydroxy-3,4-dihydroisoquinoline-2(1H)-carbaldehyde | HCID 21447038 | — |
Reaction Steps
46.0 g of 1,2,3,4-tetrahydro-6-hydroxy-isoquinoline-hydrobromide are reacted with 85 ml of formamide for 1 hour at 140° C. with stirring. After cooling to 100° C., 216 ml of water are added, whereby the reaction product crystallizes. 34.0 g of 2-formyl-1,2,3,4-tetrahydro-6-hydroxy-isoquinoline are obtained. m.p. = 185.5° - 186° C. (ethanol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04013663 |
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| Source dataset | uspto-grants-1977_03 |
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| ORD ID | ord-3aa79ced6f8a404c8534bcfc361a94b0 |
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| Source note | uspto-grants-1977_03 |
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