反应详情

23.3 g. of 6-(2,3-epoxy-propoxy)-2-formyl-1,2,3,4-tetrahydroisoquinoline are held at the boiling point under reflux with 59.1 g of isopropylamine in 100 ml of isopropanol for 5 hours. The mixture is evaporated and the residue is rubbed with 150 ml of diethyl ether. 27.5 g of 2-formyl-1,2,3,4-tetrahydro-6-(2-hydroxy-3-isopropylamino-propoxy)-isoquinoline are obtained. m.p. = 56.6° - 58° C.

1. customThe mixture is evaporated