Diethyl Malonate → HCID 86602522, compound

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Reaction Steps

The compound ##EQU36## is prepared by adding 44 grams sodium metal to 900 ml. ethanol and adding 320 grams diethyl malonate to form a slurry of sodium diethyl malonate. To this slurry, 88 grams of ethylene oxide in 300 ml. ethanol is added, the temperature being maintained in the range of 40° to 45° C. The mixture is stirred for 14 hours at a temperature of 25° C and 120 ml. glacial acetic acid is added to form the compound (1). The ethanol is distilled from the slurry under reduced pressure; 500 ml. water is added to the residue to dissolve sodium acetate; the organic product phase is separated, dissolved in ether, washed with water, dried and stripped of ether, and distilled to yield purified ##EQU37## Step 2:

Provenance & Evidence