Diethyl Malonate → HCID 86602522, compound

HRID 597312Notes

Reaction equation

HRID 597312 reaction equation
[Na:1].[C:2]([O:10][CH2:11][CH3:12])(=[O:9])[CH2:3][C:4]([O:6][CH2:7][CH3:8])=[O:5]>C(O)C>[C:4]([O:6][CH2:7][CH3:8])(=[O:5])[CH2:3][C:2]([O:10][CH2:11][CH3:12])=[O:9].[Na:1]

Participants

4

Reactant 2

HCID 7761Diethyl MalonateHCID 5360545Sodium

Product 1

HCID 86602522HCID 86602522, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The compound ##EQU36## is prepared by adding 44 grams sodium metal to 900 ml. ethanol and adding 320 grams diethyl malonate to form a slurry of sodium diethyl malonate. To this slurry, 88 grams of ethylene oxide in 300 ml. ethanol is added, the temperature being maintained in the range of 40° to 45° C. The mixture is stirred for 14 hours at a temperature of 25° C and 120 ml. glacial acetic acid is added to form the compound (1). The ethanol is distilled from the slurry under reduced pressure; 500 ml. water is added to the residue to dissolve sodium acetate; the organic product phase is separated, dissolved in ether, washed with water, dried and stripped of ether, and distilled to yield purified ##EQU37## Step 2:

Workup

  1. customThe compound ##EQU36## is prepared

Sources & evidence

ORD record
ord-6d49ed20a48e47e6af5f11bf4c07d82c
Source dataset
uspto-grants-1977_03
Patent number
US04013714

Reaction notes

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