Thionyl Chloride → [(2,2,2-Trifluoroethyl)sulfanyl]acetyl chloride

HRID 597363Notes

Reaction equation

HRID 597363 reaction equation
S(Cl)([Cl:3])=O.[F:5][C:6]([F:14])([F:13])[CH2:7][S:8][CH2:9][C:10](O)=[O:11]>>[F:5][C:6]([F:14])([F:13])[CH2:7][S:8][CH2:9][C:10]([Cl:3])=[O:11]

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 167908082-[(2,2,2-Trifluoroethyl)sulfanyl]acetic acid

Product 1

HCID 21816785[(2,2,2-Trifluoroethyl)sulfanyl]acetyl chloride

Procedure

Thionyl chloride (21.9 g, 184 mmol) and trifluoroethylmercaptoacetic acid (15.9 g, 91 mmol) were stirred together overnight. The excess reagent was removed in vacuo and the product was distilled; bp 62°-68°/20 mm.

Workup

  1. customThe excess reagent was removed in vacuo
  2. distillationthe product was distilled

Sources & evidence

ORD record
ord-4731bbfdd28c484b92a2595326397578
Source dataset
uspto-grants-1977_03
Patent number
US04013765

Reaction notes

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