反应详情

To a solution of ethyl 4-(N-(tert-butoxycarbonyl)methylsulfonamido)-thiophene-2-carboxylate (Int. 43) (300 mg, 0.859 mmol) in THF/water 1/1 (20 ml), lithium hydroxide (61.7 mg, 2.58 mmol) was added, and the mixture was reacted overnight at RT. The organic solvent was evaporated and the aqueous residue was acidified with 1N HCl (pH=5); the resulting precipitate was collected by filtration yielding 4-(N-(tert-butoxycarbonyl)-methylsulfonamido)thiophene-2-carboxylic acid (Int. 44) (220 mg, 0.685 mmol, MS/ESI+343.7 [MNa]+).

1. customthe mixture was reacted overnight at RT
2. customThe organic solvent was evaporated
3. filtrationthe resulting precipitate was collected by filtration