Methanethiol → HCID 21445088, compound

HRID 597458Notes

Reaction equation

HRID 597458 reaction equation
[CH3:1][S:2][C:3]1[N:8]=[C:7]([NH:9][CH2:10][CH3:11])[C:6]([N+:12]([O-:14])=[O:13])=[C:5](Cl)[N:4]=1.[CH3:16][SH:17]>C(N(CC)CC)C>[CH3:1][S:2][C:3]1[N:8]=[C:7]([NH:9][CH2:10][CH3:11])[C:6]([N+:12]([O-:14])=[O:13])=[C:5]([S:17][CH3:16])[N:4]=1

Participants

4

Reactant 2

HCID 878MethanethiolHCID 21445110HCID 21445110, compound

Product 1

HCID 21445088HCID 21445088, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

5 g of 2-methylthio-6-chloro-5-nitro-4-ethylamino-pyrimidine are dissolved in 50 ml of absolute alcohol and 2.5 g of triethylamine are then added. Then 1 g of methylmercaptan is passed in at 25° to 30° C over a period of 10 minutes. The mixture is stirred at room temperature for 1/2 hour and subsequently evaporated by rotary evaporation. The residue is suspended in 50 ml of water and filtered off with suction and washed once with water. The product is dried in a water yet vacuum and at room temperature over phosphorous pentoxide for 16 hours to yield 2,6-di-methylthio-5-nitro-4-ethylamino-pyrimidine with a melting point of 149°-150° C.

Workup

  1. customsubsequently evaporated by rotary evaporation
  2. filtrationfiltered off with suction
  3. washwashed once with water
  4. dry with materialThe product is dried in a water yet vacuum and at room temperature over phosphorous pentoxide for 16 hours

Sources & evidence

ORD record
ord-1a6c1aed5fa9471e82581d72af05c1c9
Source dataset
uspto-grants-1977_03
Patent number
US04014677

Reaction notes

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