3-Pentanamine → HCID 21445076, compound

HRID 597463Notes

Reaction equation

HRID 597463 reaction equation
[CH2:1]([C:5]1[N:10]=[C:9](Cl)[C:8]([N+:12]([O-:14])=[O:13])=[C:7]([Cl:15])[N:6]=1)[CH2:2][CH2:3][CH3:4].[NH2:16][CH:17]([CH2:20][CH3:21])[CH2:18][CH3:19]>C(N(CC)CC)C>[CH2:1]([C:5]1[N:6]=[C:7]([Cl:15])[C:8]([N+:12]([O-:14])=[O:13])=[C:9]([NH:16][CH:17]([CH2:20][CH3:21])[CH2:18][CH3:19])[N:10]=1)[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 2

HCID 120193-PentanamineHCID 12280647Pyrimidine, 2-butyl-4,6-dichloro-5-nitro-

Product 1

HCID 21445076HCID 21445076, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

200 ml of alcohol and 4.5 g (44 m-moles) of triethylamine are added to 11 g (44 m-moles) of 2-n-butyl-4,6-dichloro-5-nitro-pyrimidine. At -50° C, 4.0 g (44 m-moles of 3-aminopentane are added dropwise. The reaction mixture is stirred for 3 hours and then evaporated. The residue is suspended in 100 ml of water and extraction is performed with ether. The ethereal extracts are dried over MgSO4 and evaporated to yield 10.5 g of 2-n-butyl-4-chloro-5-nitro-6-(3-pentylamino)-pyrimidine (nD20 : 1.5383) as a yellow oil

Workup

  1. customevaporated
  2. extractionextraction
  3. dry with materialThe ethereal extracts are dried over MgSO4
  4. customevaporated

Sources & evidence

ORD record
ord-c56881d8bbf0483d8bf3f8acd467bb9e
Source dataset
uspto-grants-1977_03
Patent number
US04014677

Reaction notes

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