反应详情

A mixture of 31.4 parts of 2,2,6,6-tetramethylpiperidin-4-ol and 17.1 parts of benzyl bromide in 125 parts of ethyl alcohol was heated under reflux conditions for 96 hours. The cooled reaction mixture was filtered to remove 2,2,6,6-tetramethylpiperidin-4-ol hydrobromide formed during the reaction and the ethyl alcohol solvent was removed by distillation under reduced pressure. Purification of the residue by chromatography on a aluminia column using chloroform as the solvent gave 1-benzyl-2,2,6,6-tetramethylpiperidin-4-ol having a melting point of 151°-2°C and the following elemental analysis by weight

1. temperaturewas heated under reflux conditions for 96 hours
2. customThe cooled reaction mixture
3. filtrationwas filtered
4. customto remove 2,2,6,6-tetramethylpiperidin-4-ol hydrobromide
5. customformed during the reaction
6. customthe ethyl alcohol solvent was removed by distillation under reduced pressure
7. customPurification of the residue by chromatography on a aluminia column