反应详情

温度

25 °C

To the crude wet xylene solution of 3,5-diphenyl-4-methylpyrazoline (from B above), is added 1.0 g of 5% palladium on carbon catalyst. The reaction mixture is slowly heated to reflux, and the water removed by azeotropic distillation using a Dean-Stark apparatus (xylene returned to reactor). Refluxing is continued at 145° C for 4 hours. After the four-hour reflux, the reaction mixture is cooled to 25° C, and the combined 5% palladium on charcoal/3,5-diphenyl-4-methylpyrazole filtered off. The solids are slurried in warm acetone to dissolve the 3,5-diphenyl-4-methylpyrazole. The catalyst is then filtered off. Removal of the acetone in vacuo yields 1.5 g of 3,5-diphenyl-4-methylpyrazole. After recrystallization from hot xylene, pure 3,5-diphenyl-4-methylpyrazole having a melting point of 225°-226° C is obtained.

1. temperatureThe reaction mixture is slowly heated
2. temperatureto reflux
3. customthe water removed by azeotropic distillation
4. temperatureRefluxing
5. temperatureAfter the four-hour reflux
6. filtrationthe combined 5% palladium on charcoal/3,5-diphenyl-4-methylpyrazole filtered off
7. dissolutionto dissolve the 3,5-diphenyl-4-methylpyrazole
8. filtrationThe catalyst is then filtered off
9. customRemoval of the acetone in vacuo