Isopropylamine → HCID 54252847, compound

HRID 597638Notes

Reaction equation

HRID 597638 reaction equation
[C:1]([NH:4][CH:5]=[CH:6][C:7]1[CH:17]=[CH:16][C:10]([O:11][CH2:12][CH:13]2[O:15][CH2:14]2)=[CH:9][CH:8]=1)(=[O:3])[CH3:2].[CH:18]([NH2:21])([CH3:20])[CH3:19]>C(O)(C)C>[C:1]([NH:4][CH:5]=[CH:6][C:7]1[CH:17]=[CH:16][C:10]([O:11][CH2:12][CH:13]([OH:15])[CH2:14][NH:21][CH:18]([CH3:20])[CH3:19])=[CH:9][CH:8]=1)(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 6363IsopropylamineHCID 54559983HCID 54559983, compound

Product 1

HCID 54252847HCID 54252847, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

11.6 g (0.05 mol) of 1-[p-(2-acetylaminovinyl)-phenoxy]-2,3-epoxy-propane are dissolved in 100 ml of isopropanol, 4.25 ml (0.05 mol) of isopropylamine are added and thereafter the mixture is heated to the boil for 3 hours under reflux. It is then evaporated in vacuo and the resulting crude base is crystallised from ethyl acetate. 1-[p-(2-Acetylaminovinyl)-phenoxy]-2-hydroxy-3-isopropylaminopropane of melting point 144°-146°C is obtained.

Workup

  1. temperaturethe mixture is heated to the boil for 3 hours
  2. temperatureunder reflux
  3. customIt is then evaporated in vacuo
  4. customthe resulting crude base is crystallised from ethyl acetate

Sources & evidence

ORD record
ord-c5127d338f544c7f996dd769753e2d6f
Source dataset
uspto-grants-1977_03
Patent number
US04014920

Reaction notes

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