Hydrochloric Acid → HCID 178424140, compound

Participants

Reaction Conditions

Reaction Steps

6 g (13.7 mmol) of [trans-4-(2-o-tolyl-chroman-6-yloxy)-cyclohexyl]-carbamic acid tert-butyl ester were dissolved in 50 ml of 1,4-dioxane and 25 ml of 2N hydrogen chloride in diethyl ether. The diethyl ether was removed by evaporation and the remaining solution was refluxed until no starting material could be detected by RP-HPLC. The resulting suspension was cooled to 0° C. and the crystals were collected by filtration, washed once with cold methyl tert-butyl ether and dried in vacuum at 25° C. to yield 3.6 g of the title compound.

Provenance & Evidence