反应详情

温度

0 °C

6 g (13.7 mmol) of [trans-4-(2-o-tolyl-chroman-6-yloxy)-cyclohexyl]-carbamic acid tert-butyl ester were dissolved in 50 ml of 1,4-dioxane and 25 ml of 2N hydrogen chloride in diethyl ether. The diethyl ether was removed by evaporation and the remaining solution was refluxed until no starting material could be detected by RP-HPLC. The resulting suspension was cooled to 0° C. and the crystals were collected by filtration, washed once with cold methyl tert-butyl ether and dried in vacuum at 25° C. to yield 3.6 g of the title compound.

1. customThe diethyl ether was removed by evaporation
2. temperaturethe remaining solution was refluxed until no starting material
3. filtrationthe crystals were collected by filtration
4. washwashed once with cold methyl tert-butyl ether
5. customdried in vacuum at 25° C.