2-(Diisopropylamino)ethyl chloride → HCID 21446124、化合物

HRID 597711ノート

反応式

HRID 597711 の反応式
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH:16]3[C:11]([CH2:12][CH2:13][CH2:14][CH2:15]3)=[CH:10][C:9]2=[O:17])=[CH:4][CH:3]=1.CC(C)([O-])C.[K+].[CH:24]([N:27]([CH:31]([CH3:33])[CH3:32])[CH2:28][CH2:29]Cl)([CH3:26])[CH3:25]>C(O)(C)(C)C>[CH:24]([N:27]([CH:31]([CH3:33])[CH3:32])[CH2:28][CH2:29][O:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[CH:16]3[C:11]([CH2:12][CH2:13][CH2:14][CH2:15]3)=[CH:10][C:9]2=[O:17])=[CH:6][CH:7]=1)([CH3:26])[CH3:25]

参加物

5

反応物 3

HCID 73122-(Diisopropylamino)ethyl chlorideHCID 21446101HCID 21446101、化合物HCID 23665647Potassium tert-butoxide

生成物 1

HCID 21446124HCID 21446124、化合物収率 76%

試薬・触媒・溶媒 1

HCID 6386tert-Butanol溶媒

実験手順

22.9 g (0.1 mol) of 1-(4-hydroxyphenyl)-2-oxo-2,4,5,6,7,7a-hexahydro-indole were dissolved, as in Example 4, in a solution of 0.1 mol of potassium tertiary-butoxide in 100 cm3 of tertiary-butanol, and then reacted with 18 g (0.11 mol) of 2-diisopropylamino-1-chloroethane. After conventional treatment of the reaction product, and crystallization from heptane, 27 g (yield 76%) of 1-[4-(2-diisopropyaminoethoxy)-phenyl]-2-oxo-2,4,5,6,7,7a-hexahydro-indole were obtained; m.p. 86° C.

後処理

  1. customAfter conventional treatment of the reaction product, and crystallization from heptane

出典と根拠

ORDレコード
ord-741d23744edb4ec89905896dccfacd16
出典データセット
uspto-grants-1977_03
特許番号
US04015002

反応ノート

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